Sodium Hydroxide → 3-Chloro-4-(1-methyl-3-indolylcarbonylamino)phenylacetic acid

Participants

Reaction Steps

Ethyl (3-chloro-4-((1-methyl-3-indolylcarbonyl)amino)phenyl)acetate (639 mg, 1.72 mmol) was dissolved in THF (17.5 ml). To the resulting solution was added 0.25N NaOH (10.3 ml, 2.58 mmol), followed by stirring at room temperature for 4 hours. The reaction mixture was poured in 1N HCl (15 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (3-chloro-4-((1-methyl-3-indolylcarbonyl)amino)phenyl)acetic acid (549 mg, 93%) as a colorless solid.

Provenance & Evidence