6-Bromoindole → HCID 11336128, compound

Participants

Reaction Steps

The product of Example 2A (300 mg, 0.8 mmol) was coupled with 6-bromoindole (Aldrich, 196 mg, 1 mmol) according to the procedure in 2B. The title compound was purified by chromatography (SiO2, CH2Cl2:MeOH:NH3.H2O, 90:10:1, Rf. 0.20) as a solid (30 mg, yield, 12%). 1H NMR (300 MHz, CD3OD) δ 1.45–1.58 (m, 1H), 1.64–1.90 (m, 2H), 2.01–2.15 (m, 1H), 2.17–2.24 (m, 1H), 2.75–3.04 (m, 5H), 3.30–3.42 (m, 1H), 4.53–4.61 (m, 1H), 6.43 (dd, J=3.1, 0.7 Hz, 1H), 6.97 (dt, J=8.8, 2.6 Hz, 2H), 7.21–7.27 (m, 2H), 7.52–7.60 (m, 4H) ppm. MS (DCl/NH3): m/z 319 (M+H)+.

Provenance & Evidence