Fumaric Acid → 5-{6-[(3R)-1-azabicyclo[2.2.2]oct-3-yloxy]pyridazin-3-yl}-3-methyl-1H-indole Fumarate

Participants

Reaction Steps

The product of Example 10B (40 mg, 0.12 mmol) was treated with fumaric acid (23 mg, 0.2 mmol) in EtOAc/EtOH (v. 1:1, 5 mL) at ambient temperature for 10 h. The title compound was obtained as solid (40 mg, yield, 62%). 1H NMR (300 MHz, CD3OD) δ 1.90–2.24 (m, 3H), 2.33–2.48 (m, 4H), 2.61–2.68 (m, 1H), 3.22–3.53 (m, 5H), 3.93–4.03 (m, 1H), 5.51–5.58 (m, 1H), 6.70 (s, 3.6H), 7.08 (d, J=1.0 Hz, 1H), 7.32 (d, J=9.5 Hz, 1H), 7.45 (d, J=8.5 Hz, 1H), 7.72 (dd, J=8.8, 1.7 Hz, 1H), 8.10 (d, J=1.7 Hz, 1H), 8.17 (d, J=9.5 Hz, 1H) ppm. MS (DCl/NH3): m/z 335 (M+H)+. Anal. Calculated for C20H22N4O.1.8C4H4O4: C, 60.13; H, 5.42; N, 10.31. Found: C, 60.02; H, 5.53; N, 10.27.

Provenance & Evidence