HCID 21072872, compound → HCID 178515246, compound

Participants

Reaction Steps

415 mg (1.29 mmol) of 1-(4-methoxybenzyl)-1H-[1,2,3]triazolo[4,5-g]phthalazin-4,9-dione was dissolved in 30 ml of TFA and refluxed for 2 days. TFA was removed under reduced pressure and 100 ml of 1M NaOH was added to residue, followed by washing with ethyl acetate. The resulting aqueous layer was acidified to pH 1 with HCl, and extracted with ethyl acetate. 150 mg of light brown powder was obtained by drying and concentrating the organic layer (yield 58%).

Provenance & Evidence