反应详情

A suspension of 5.20 g (16.45 mmol) 1-(2-nitro-phenyl)-cyclohexanol and 500 mg Raney nickel in EtOH (70 mL) is hydrogenated at RT and under 3 bar hydrogen pressure for 4 h. The catalyst is filtered off through Celite and the filtrate is evaporated down in vacuo. The residue is recrystallised from hexane. Yield: 1.53 g (49%); Rf=0.38 (silica gel, hexane/EtOAc 4:1); ESI-MS: [M+H—H2O]+=174.

1. filtrationThe catalyst is filtered off through Celite
2. customthe filtrate is evaporated down in vacuo
3. customThe residue is recrystallised from hexane