Diethyl Ether → HCID 10436182, compound

Participants

Reaction Conditions

Reaction Steps

Solid 3-[8-(2-Phenyl-imidazol-1-yl)-imidazo[1,2-a]Pyrazin-6-yl]-phenylamine (50 mg) (7) is added to an anhydrous 0.2 M solution of (4-Chloro-phenyl)-acetyl chloride in toluene (0.7 mL) at room temperature, and 0.25 ml of anhydrous DMF is subsequently added to solubilize the reagents. The reaction is warmed to 50° C. and stirred under N2 for 3 hours. The reaction is cooled to room temperature. Diethyl ether (15 ml) is then added slowly and the resulting tan solid 2-(4-Chloro-phenyl)-N-{3-[8-(2-phenyl-imidazol-1-yl)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-acetamide (60 mg) (8) is filtered and washed with diethyl ether and dried under vacuum.

Provenance & Evidence