HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-methoxy-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid → (-)-2-methoxy-N-(6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N'-(2,2,3,3,3-pentafluoro-propyl)-malonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-methoxy-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid | HCID 21072493 | — |
| Reactant | (7S)-7-Amino-5,7-dihydro-6H-dibenzo[b,d]azepin-6-one | HCID 25067537 | — |
| Product | (-)-2-methoxy-N-(6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N'-(2,2,3,3,3-pentafluoro-propyl)-malonamide | HCID 11155654 | — |
Reaction Steps
(S)-7-Amino-5H,7H-dibenzo[b,d]azepin-6-one was coupled with 2-methoxy-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid in analogy to the description in examples 65 and 66 to yield (−)-2-methoxy-N-(6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N′-(2,2,3,3,3-pentafluoro-propyl)-malonamide as white solid,
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07160875B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-3def7af7f2244e04a7686278855475e7 |
| Source note | uspto-grants-2007_01 |