N-(3,3,4,4,4-pentafluoro-butyl)-malonamic acid → HCID 86596824, compound

HRID 1372953Notes

Reaction equation

HRID 1372953 reaction equation
[NH2:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH2:10][CH:11]2[CH2:13][CH2:12]2)[C:6]2[CH:14]=[CH:15][CH:16]=[CH:17][C:5]=2[C:4]2[CH:18]=[CH:19][CH:20]=[CH:21][C:3]1=2.[F:22][C:23]([F:37])([C:33]([F:36])([F:35])[F:34])[CH2:24][CH2:25][NH:26][C:27](=[O:32])[CH2:28][C:29](O)=[O:30]>>[CH:11]1([CH2:10][N:7]2[C:8](=[O:9])[C@@H:2]([NH:1][C:29](=[O:30])[CH2:28][C:27]([NH:26][CH2:25][CH2:24][C:23]([F:22])([F:37])[C:33]([F:36])([F:34])[F:35])=[O:32])[C:3]3[CH:21]=[CH:20][CH:19]=[CH:18][C:4]=3[C:5]3[CH:17]=[CH:16][CH:15]=[CH:14][C:6]2=3)[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 21072536N-(3,3,4,4,4-pentafluoro-butyl)-malonamic acidHCID 68916092HCID 68916092, compound

Product 1

HCID 86596824HCID 86596824, compound

Procedure

(S)-7-amino-5-cyclopropylmethyl-5H,7H-dibenzo[b,d]azepin-6-one was coupled with N-(3,3,4,4,4-pentafluoro-butyl)-malonamic acid in analogy to the description in example 73 to yield N-((S)-5-cyclopropylmethyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N′-(3,3,4,4,4-pentafluoro-butyl)-malonamide as white solid.

Sources & evidence

ORD record
ord-3575efea8ed3484490edd3826841b158
Source dataset
uspto-grants-2007_01
Patent number
US07160875B2

Reaction notes

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