HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-methyl-N-(3,3,4,4,4-pentafluoro-butyl)-malonamic acid → N-((S)-5-cyclopropylmethyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-2-methyl-N'-(3,3,4,4,4-pentafluoro-butyl)-malonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-methyl-N-(3,3,4,4,4-pentafluoro-butyl)-malonamic acid | HCID 21072497 | — |
| Reactant | HCID 68916092 | HCID 68916092 | — |
| Product | N-((S)-5-cyclopropylmethyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-2-methyl-N'-(3,3,4,4,4-pentafluoro-butyl)-malonamide | HCID 86596826 | — |
Reaction Steps
(S)-7-amino-5-cyclopropylmethyl-5H,7H-dibenzo[b,d]azepin-6-one was coupled with 2-methyl-N-(3,3,4,4,4-pentafluoro-butyl)-malonamic acid in analogy to the description in example 73 to yield N-((S)-5-cyclopropylmethyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-2-methyl-N′-(3,3,4,4,4-pentafluoro-butyl)-malonamide (epimers) as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07160875B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-884491159d104a21a61150272e3b156e |
| Source note | uspto-grants-2007_01 |