HCID 21072520, compound → HCID 86596829, compound

HRID 1372958Notes

Reaction equation

HRID 1372958 reaction equation
[NH2:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][C:3]1=2.[F:19][C:20]([F:33])([C:29]([F:32])([F:31])[F:30])[CH2:21][NH:22][C:23](=[O:28])[CH2:24][C:25](O)=[O:26]>>[CH3:10][N:7]1[C:8](=[O:9])[C@@H:2]([NH:1][C:25](=[O:26])[CH2:24][C:23]([NH:22][CH2:21][C:20]([F:33])([F:19])[C:29]([F:30])([F:32])[F:31])=[O:28])[C:3]2[CH:18]=[CH:17][CH:16]=[CH:15][C:4]=2[C:5]2[CH:14]=[CH:13][CH:12]=[CH:11][C:6]1=2

Participants

3

Reactant 2

HCID 21072520HCID 21072520, compoundHCID 59100698(7S)-7-Amino-5-methyl-5,7-dihydro-6H-dibenzo[b,d]azepin-6-one

Product 1

HCID 86596829HCID 86596829, compound

Procedure

(S)-7-Amino-5-methyl-5H,7H-dibenzo[b,d]azepin-6-one was coupled with N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid in analogy to the description in example 73 to yield N-((S)-5-Methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N′-(2,2,3,3,3-pentafluoro-propyl)-malonamide as white solid.

Sources & evidence

ORD record
ord-dd27025e7d7647e58696e37e15552538
Source dataset
uspto-grants-2007_01
Patent number
US07160875B2

Reaction notes

Loading…