(S)-2-fluoro-2-methyl-malonic acid monoethyl ester → HCID 69037760, compound

HRID 1372959Notes

Reaction equation

HRID 1372959 reaction equation
[NH2:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][C:3]1=2.[CH2:19]([O:21][C:22](=[O:29])[C@:23]([F:28])([CH3:27])[C:24](O)=[O:25])[CH3:20]>>[CH2:19]([O:21][C:22](=[O:29])[C@:23]([F:28])([CH3:27])[C:24]([NH:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][C:3]1=2)=[O:25])[CH3:20]

Participants

3

Reactant 2

HCID 13350487(S)-2-fluoro-2-methyl-malonic acid monoethyl esterHCID 59100698(7S)-7-Amino-5-methyl-5,7-dihydro-6H-dibenzo[b,d]azepin-6-one

Product 1

HCID 69037760HCID 69037760, compound

Procedure

In an analogous manner to that described in Example 1 a), the condensation of (S)-7-amino-5-methyl-5H,7H-dibenzo[b,d]azepin-6-one and (2S)-2-fluoro-2-methyl-malonic acid mono ethyl ester yielded the title compound as a colourless oil;

Sources & evidence

ORD record
ord-cbe6373d804245a690c1d715d78fdfaa
Source dataset
uspto-grants-2007_01
Patent number
US07160875B2

Reaction notes

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