(7S)-7-Amino-5-methyl-5,7-dihydro-6H-dibenzo[b,d]azepin-6-one → HCID 86596831, compound

HRID 1372961Notes

Reaction equation

HRID 1372961 reaction equation
[NH2:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][C:3]1=2.[F:19][C@@:20]([CH3:35])([C:24]([NH:26][CH2:27][C:28]([F:34])([F:33])[C:29]([F:32])([F:31])[F:30])=[O:25])[C:21](O)=[O:22]>>[F:19][C@@:20]([CH3:35])([C:24]([NH:26][CH2:27][C:28]([F:33])([F:34])[C:29]([F:32])([F:30])[F:31])=[O:25])[C:21]([NH:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][C:3]1=2)=[O:22]

Participants

3

Reactant 2

HCID 59100698(7S)-7-Amino-5-methyl-5,7-dihydro-6H-dibenzo[b,d]azepin-6-oneHCID 86596832HCID 86596832, compound

Product 1

HCID 86596831HCID 86596831, compound

Procedure

In an analogous manner to that described in Example 20 d), the condensation of (S)-7-amino-5-methyl-5H,7H-dibenzo[b,d]azepin-6-one and (2S)-2-fluoro-2-methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid yielded the title compound as a white solid;

Workup

  1. customdescribed in Example 20 d

Sources & evidence

ORD record
ord-28412bf933ed4694b979bed053623857
Source dataset
uspto-grants-2007_01
Patent number
US07160875B2

Reaction notes

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