N-(3,3,4,4,4-pentafluoro-butyl)-malonamic acid → HCID 86596834, compound

HRID 1372963Notes

Reaction equation

HRID 1372963 reaction equation
[NH2:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][C:3]1=2.[F:19][C:20]([F:34])([C:30]([F:33])([F:32])[F:31])[CH2:21][CH2:22][NH:23][C:24](=[O:29])[CH2:25][C:26](O)=[O:27]>>[CH3:10][N:7]1[C:8](=[O:9])[C@@H:2]([NH:1][C:26](=[O:27])[CH2:25][C:24]([NH:23][CH2:22][CH2:21][C:20]([F:19])([F:34])[C:30]([F:33])([F:31])[F:32])=[O:29])[C:3]2[CH:18]=[CH:17][CH:16]=[CH:15][C:4]=2[C:5]2[CH:14]=[CH:13][CH:12]=[CH:11][C:6]1=2

Participants

3

Reactant 2

HCID 21072536N-(3,3,4,4,4-pentafluoro-butyl)-malonamic acidHCID 59100698(7S)-7-Amino-5-methyl-5,7-dihydro-6H-dibenzo[b,d]azepin-6-one

Product 1

HCID 86596834HCID 86596834, compound

Procedure

(S)-7-Amino-5-methyl-5H,7H-dibenzo[b,d]azepin-6-one was coupled with N-(3,3,4,4,4-pentafluoro-butyl)-malonamic acid in analogy to the description example 73 to yield N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N′-(3,3,4,4,4-pentafluoro-butyl)malonamide as white solid.

Sources & evidence

ORD record
ord-fea38cfbb4d346429044dc5651272926
Source dataset
uspto-grants-2007_01
Patent number
US07160875B2

Reaction notes

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