HCID 21072510, compound → HCID 86596835, compound

HRID 1372964Notes

Reaction equation

HRID 1372964 reaction equation
[NH2:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][C:3]1=2.[F:19][C:20]([CH3:36])([C:24]([NH:26][CH2:27][CH2:28][C:29]([F:35])([F:34])[C:30]([F:33])([F:32])[F:31])=[O:25])[C:21](O)=[O:22]>>[F:19][C:20]([CH3:36])([C:24]([NH:26][CH2:27][CH2:28][C:29]([F:34])([F:35])[C:30]([F:33])([F:32])[F:31])=[O:25])[C:21]([NH:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][C:3]1=2)=[O:22]

Participants

3

Reactant 2

HCID 21072510HCID 21072510, compoundHCID 59100698(7S)-7-Amino-5-methyl-5,7-dihydro-6H-dibenzo[b,d]azepin-6-one

Product 1

HCID 86596835HCID 86596835, compound

Procedure

In an analogous manner to that described in Example 20 d), the condensation of (S)-7-amino-5-methyl-5H,7H-dibenzo[b,d]azepin-6-one and (2RS)-2-fluoro-2-methyl-N-(3,3,4,4,4-pentafluoro-butyl)-malonamic acid yielded the title compound as a white solid;

Workup

  1. customdescribed in Example 20 d

Sources & evidence

ORD record
ord-1105bc189dbf414a802c9ef65f42d8a1
Source dataset
uspto-grants-2007_01
Patent number
US07160875B2

Reaction notes

Loading…