HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-methyl-N-(3,3,4,4,4-pentafluoro-butyl)-malonamic acid → (2RS)-2-Methyl-N-[(S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-N'-(3,3,4,4,4-pentafluoro-butyl)-malonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-methyl-N-(3,3,4,4,4-pentafluoro-butyl)-malonamic acid | HCID 21072497 | — |
| Reactant | (7S)-7-Amino-5,7-dihydro-5-methyl-6H-dibenz[b,d]azepin-6-one | HCID 59100698 | — |
| Product | (2RS)-2-Methyl-N-[(S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-N'-(3,3,4,4,4-pentafluoro-butyl)-malonamide | HCID 86596837 | — |
Reaction Steps
In an analogous manner to that described in Example 20 d), the condensation of (S)-7-amino-5-methyl-5H,7H-dibenzo[b,d]azepin-6-one and (2RS)-2-methyl-N-(3,3,4,4,4-pentafluoro-butyl)-malonamic acid yielded the title compound as a white solid;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07160875B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-ece32f641f96433f99d1593fd02e5ba0 |
| Source note | uspto-grants-2007_01 |