HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pivaloyl chloride → [(3S)-5-(2,2-Dimethyl-propionyl)-1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pivaloyl chloride | HCID 62493 | — |
| Reactant | (S)-tert-Butyl (1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)carbamate | HCID 57617767 | — |
| Product | [(3S)-5-(2,2-Dimethyl-propionyl)-1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester | HCID 69042305 | — |
Reaction Steps
In an analogous manner to that described in Example 103b), the acylation of (S)-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-carbamic acid tert-butyl ester with pivaloyl chloride yielded the title compound as a white solid; MS: m/e=376 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07160875B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-52573eb294364658a6926fb8806b8fa4 |
| Source note | uspto-grants-2007_01 |