HCID 21072520, compound → HCID 86596844, compound

HRID 1372970Notes

Reaction equation

HRID 1372970 reaction equation
Cl.[NH2:2][C@@H:3]1[C:9](=[O:10])[N:8]([CH3:11])[C:7]2[CH:12]=[CH:13][CH:14]=[CH:15][C:6]=2[N:5]([C:16](=[O:21])[C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:4]1.[F:22][C:23]([F:36])([C:32]([F:35])([F:34])[F:33])[CH2:24][NH:25][C:26](=[O:31])[CH2:27][C:28](O)=[O:29]>>[CH3:19][C:17]([CH3:18])([CH3:20])[C:16]([N:5]1[CH2:4][C@H:3]([NH:2][C:28](=[O:29])[CH2:27][C:26]([NH:25][CH2:24][C:23]([F:36])([F:22])[C:32]([F:33])([F:35])[F:34])=[O:31])[C:9](=[O:10])[N:8]([CH3:11])[C:7]2[CH:12]=[CH:13][CH:14]=[CH:15][C:6]1=2)=[O:21]

Participants

3

Reactant 2

HCID 21072520HCID 21072520, compoundHCID 69038213HCID 69038213, compound

Product 1

HCID 86596844HCID 86596844, compound

Procedure

In an analogous manner to that described in Example 20 d), the condensation of (S)-3-amino-5-(2,2-dimethyl-propionyl)-1-methyl-1,3,4,5-tetrahydro-benzo[b][1,4]diazepin-2-one hydrochloride and N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid yielded the title compound as a white foam;

Workup

  1. customdescribed in Example 20 d

Sources & evidence

ORD record
ord-0928f46746414fe49ea5e956faa017ac
Source dataset
uspto-grants-2007_01
Patent number
US07160875B2

Reaction notes

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