HCID 21072487, compound → HCID 86596846, compound

HRID 1372974Notes

Reaction equation

HRID 1372974 reaction equation
Cl.[C:2]([N:5]1[CH2:11][C@H:10]([NH2:12])[C:9](=[O:13])[N:8]([CH3:14])[C:7]2[CH:15]=[CH:16][CH:17]=[CH:18][C:6]1=2)(=[O:4])[CH3:3].[F:19][C:20]([CH3:35])([C:24]([NH:26][CH2:27][C:28]([F:34])([F:33])[C:29]([F:32])([F:31])[F:30])=[O:25])[C:21](O)=[O:22]>>[C:2]([N:5]1[CH2:11][C@H:10]([NH:12][C:21](=[O:22])[C:20]([F:19])([CH3:35])[C:24]([NH:26][CH2:27][C:28]([F:33])([F:34])[C:29]([F:30])([F:32])[F:31])=[O:25])[C:9](=[O:13])[N:8]([CH3:14])[C:7]2[CH:15]=[CH:16][CH:17]=[CH:18][C:6]1=2)(=[O:4])[CH3:3]

Participants

3

Reactant 2

HCID 21072487HCID 21072487, compoundHCID 21076593HCID 21076593, compound

Product 1

HCID 86596846HCID 86596846, compound

Procedure

In an analogous manner to that described in Example 20 d), the condensation of (S)-5-acetyl-3-amino-1-methyl-1,3,4,5-tetrahydro-benzo[b][1,4]diazepin-2-one hydrochloride and 2-fluoro-2-methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid yielded the title compound as a white foam;

Workup

  1. customdescribed in Example 20 d

Sources & evidence

ORD record
ord-03140cd341514ce0961ed3570a90970a
Source dataset
uspto-grants-2007_01
Patent number
US07160875B2

Reaction notes

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