2-Methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid → HCID 86760354, compound

HRID 1372976Notes

Reaction equation

HRID 1372976 reaction equation
[C:1]([N:4]1[CH2:10][C@H:9]([NH2:11])[C:8](=[O:12])[N:7]([CH2:13][CH3:14])[C:6]2[CH:15]=[CH:16][CH:17]=[CH:18][C:5]1=2)(=[O:3])[CH3:2].[CH3:19][CH:20]([C:24]([NH:26][CH2:27][C:28]([F:34])([F:33])[C:29]([F:32])([F:31])[F:30])=[O:25])[C:21](O)=[O:22]>>[C:1]([N:4]1[CH2:10][C@H:9]([NH:11][C:21](=[O:22])[CH:20]([CH3:19])[C:24]([NH:26][CH2:27][C:28]([F:33])([F:34])[C:29]([F:30])([F:31])[F:32])=[O:25])[C:8](=[O:12])[N:7]([CH2:13][CH3:14])[C:6]2[CH:15]=[CH:16][CH:17]=[CH:18][C:5]1=2)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 210724942-Methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acidHCID 69038935HCID 69038935, compound

Product 1

HCID 86760354HCID 86760354, compound

Procedure

In an analogous manner to that described in Example 20 d) and 27, the condensation of (S)-5-acetyl-3-amino-1-ethyl-1,3,4,5-tetrahydro-benzo[b][1,4]diazepin-2-one and (2RS)-methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid [see Example 25 b)] yielded the title compound as a white solid;

Workup

  1. customdescribed in Example 20 d

Sources & evidence

ORD record
ord-05829ff1a43842a48548480a9f69c28a
Source dataset
uspto-grants-2007_01
Patent number
US07160875B2

Reaction notes

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