2-Methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid → HCID 86596848, compound

HRID 1372977Notes

Reaction equation

HRID 1372977 reaction equation
[C:1]([N:4]1[CH2:10][C@H:9]([NH2:11])[C:8](=[O:12])[N:7]([CH:13]([CH3:15])[CH3:14])[C:6]2[CH:16]=[CH:17][CH:18]=[CH:19][C:5]1=2)(=[O:3])[CH3:2].[CH3:20][CH:21]([C:25]([NH:27][CH2:28][C:29]([F:35])([F:34])[C:30]([F:33])([F:32])[F:31])=[O:26])[C:22](O)=[O:23]>>[C:1]([N:4]1[CH2:10][C@H:9]([NH:11][C:22](=[O:23])[CH:21]([CH3:20])[C:25]([NH:27][CH2:28][C:29]([F:34])([F:35])[C:30]([F:31])([F:32])[F:33])=[O:26])[C:8](=[O:12])[N:7]([CH:13]([CH3:15])[CH3:14])[C:6]2[CH:16]=[CH:17][CH:18]=[CH:19][C:5]1=2)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 210724942-Methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acidHCID 69037761HCID 69037761, compound

Product 1

HCID 86596848HCID 86596848, compound

Procedure

In an analogous manner to that described in Example 20 d) and 27, the condensation of (S)-5-acetyl-3-amino-1-isopropyl-1,3,4,5-tetrahydro-benzo[b][1,4]diazepin-2-one and (2RS)-methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid [see Example 25 b)] yielded the title compound as a white solid; MS: m/e=493 (M+H)+.

Workup

  1. customdescribed in Example 20 d

Sources & evidence

ORD record
ord-47a53372e68a4b07908a82117851813b
Source dataset
uspto-grants-2007_01
Patent number
US07160875B2

Reaction notes

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