Ammonia → HCID 135788038, compound

HRID 1372985Notes

Reaction equation

HRID 1372985 reaction equation
[OH:1][CH:2]([CH2:26][N:27]1[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]1)[CH2:3][O:4][C:5]1[CH:14]=[C:13]2[C:8]([C:9](=[O:23])[N:10](COC(=O)C(C)(C)C)[CH:11]=[N:12]2)=[CH:7][C:6]=1[O:24][CH3:25].N>CO>[OH:1][CH:2]([CH2:26][N:27]1[CH2:28][CH2:29][N:30]([CH3:33])[CH2:31][CH2:32]1)[CH2:3][O:4][C:5]1[CH:14]=[C:13]2[C:8]([C:9](=[O:23])[NH:10][CH:11]=[N:12]2)=[CH:7][C:6]=1[O:24][CH3:25]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 17974617HCID 17974617, compound

Product 1

HCID 135788038HCID 135788038, compoundYield 104.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 7-[2-hydroxy-3-(4-methylpiperazin-1-yl)propoxy]-6-methoxy-3-(pivaloyloxymethyl)-3,4-dihydroquinazolin-4-one (4.3 g, 9.3 mmol) in methanol saturated with ammonia (100 ml) was stirred for 2 days at ambient temperature. The volatiles were removed under vacuum and the residue was triturated with ether, filtered, washed with ether and dried under vacuum to give 7-(2-hydroxy-3-(4-methylpiperazin-1-yl)propoxy)-6-methoxyquinazolin-4-one (3.4 g, quant.).

Workup

  1. customThe volatiles were removed under vacuum
  2. customthe residue was triturated with ether
  3. filtrationfiltered
  4. washwashed with ether
  5. customdried under vacuum

Sources & evidence

ORD record
ord-99ac89a0f8ad4fd4b7be982ea7bd373d
Source dataset
uspto-grants-2007_01
Patent number
US07160889B2

Reaction notes

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