HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(Dimethylamino)piperidine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | Triacetoxyborohydride | HCID 2724942 | — |
| Reactant | 4-Boc-piperidinone | HCID 22318161 | — |
| Reactant | Tert-butyl 4-(dimethylamino)piperidine-1-carboxylate | HCID 22591376 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 4-(Dimethylamino)piperidine dihydrochloride | HCID 22591440 | — |
Reaction Steps
Dimethylamine hydrochloride (430 mg) was added to a methylene chloride (10 ml) solution containing 4-(tert-butoxycarbonyl)piperidone (1.0 g), and under ice-cooling, triethylamine (0.84 ml) and triacetoxyborohydride (1.17 g) were further added thereto, and the mixture was stirred at room temperature for 3 hours to undergo reaction, thereby obtaining N-tert-butoxycarbonyl-4-dimethylaminopiperidine. This compound was acid-treated with hydrochloric acid to obtain 4-(dimethylamino)piperidine-dihydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07160877B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-37ea7e00cb64456e9762af9786c415b8 |
| Source note | uspto-grants-2007_01 |