Tert-butyl 3-oxopyrrolidine-1-carboxylate → HCID 23112167, compound

Participants

Reaction Steps

A solution of Intermediate 1 (251 mg), and tert-butyl 3-oxo-1-pyrrolidinecarboxylate (563 mg, AstaTech) in dichloromethane (85 ml) was added with titanium tetraisopropoxide (905 μl, Aldrich) at room temperature, and stirred at room temperature for 19 hours. The reaction mixture was added with methanol (6 ml), and sodium borohydride (249 mg, Kanto Chemicals), and stirred at room temperature for 3.5 hours. The reaction mixture was added with saturated aqueous sodium hydrogencarbonate (20 ml), and ethyl acetate (20 ml), and then the precipitates were removed by filtration. Then, the organic layer was separated, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=4:1) to obtain the title compound (321 mg).

Provenance & Evidence