Sodium Hydroxide → HCID 23112177, compound

Participants

Reaction Conditions

Reaction Steps

The 5-nitro-4-vinylisoquinoline N-oxide (27 g) obtained in Step B mentioned above was suspended in chloroform (300 ml), and added dropwise with phosphorus oxychloride (22.3 ml, Wako Pure Chemical Industries) under ice cooling. After the addition, the reaction mixture was warmed to 60° C., and stirred at the same temperature for one hour. The reaction mixture was poured into in ice water, and neutralized with 2 N sodium hydroxide with stirring. The organic layer was separated, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to obtain the title compound (15 g).

Provenance & Evidence