Sodium Hydroxide → HCID 23112159, compound

Participants

Reaction Steps

The 1-chloro-5-nitro-4-vinylisoquinoline (15 g) obtained in Step C mentioned above was dissolved in ethyl acetate (700 ml), added with stannous chloride dihydrate (72 g), and stirred for two hours. The reaction mixture was poured on ice, and then added with 5 N aqueous sodium hydroxide. The organic layer was separated, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and then the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=3:1) to obtain the title compound (10 g).

Provenance & Evidence