反应详情

3-Methylsulfonyl-5-nitrobenzoic acid (D11) (7.5 g) was dissolved in methanol (250 ml) and Raney nickel was added. The mixture was stirred under hydrogen at atmospheric pressure and room temperature overnight. The mixture was heated to dissolve precipitated product and filtered hot. The filter cake was washed with hot MeOH and the combined filtrates were evaporated to give D12 (5.97 g) an off-white solid.

1. temperatureThe mixture was heated
2. dissolutionto dissolve
3. customprecipitated product
4. filtrationfiltered hot
5. washThe filter cake was washed with hot MeOH
6. customthe combined filtrates were evaporated