HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methylsulfonyl-5-(2-oxopyrrolidin-1-yl)benzoic acid → N-[(1S,2S,4R)-1-Benzyl-4-(bicyclo[2.2.1]hept-2-ylcarbamoyl)-2-hydroxypentyl]3-methylsulfonyl-5-(2-oxopyrrolidin-1-yl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methylsulfonyl-5-(2-oxopyrrolidin-1-yl)benzoic acid | HCID 21074199 | — |
| Reactant | N-[(1S,2S,4R)-1-Benzyl-4-(3,3-dimethylbutylcarbamoyl)-2-hydroxypentyl]-3-methanesulfonyl-benzamide | HCID 58780868 | — |
| Reactant | (2R,4S,5S)-5-Amino-4-hydroxy-2-methyl-6-phenylhexanoic acid (bicyclo[2.2.1]hept-2-yl)amide | HCID 68889549 | — |
| Product | N-[(1S,2S,4R)-1-Benzyl-4-(bicyclo[2.2.1]hept-2-ylcarbamoyl)-2-hydroxypentyl]3-methylsulfonyl-5-(2-oxopyrrolidin-1-yl)-benzamide | HCID 69507541 | — |
Reaction Steps
Prepared in an analogous manner to E1, from 3-methylsulfonyl-5-(2-oxopyrrolidin-1-yl)-benzoic acid (D19) and (2R,4S,5S)-5-Amino-4-hydroxy-2-methyl-6-phenylhexanoic acid (bicyclo[2.2.1]hept-2-yl)amide (D4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07160905B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-34da982ab01e408c83eaa6e90f5a97bc |
| Source note | uspto-grants-2007_01 |