HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1373124Generated: October 30, 2026
4-Nitrobenzyl chloride → 1-Boc-4-(4-Nitrobenzyl)piperazine
https://huagongshe.com/reaction/1373124
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Nitrobenzyl chloride | HCID 7482 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Boc-4-(4-Nitrobenzyl)piperazine | HCID 23506946 | — |
Reaction Steps
A mixture of 10.6 g (57 mmol) of N-tert.butoxycarbonyl-piperazine, 10.8 g (62.7 mmol) of 4-nitrobenzylchloride, 23.8 ml (171 mmol) of triethylamine in 100 ml of dichloromethane is stirred for 12 hours at 70° C. After diluting with water the organic phase is separated off, dried and evaporated down.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07160901B2 |
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| Source dataset | uspto-grants-2007_01 |
|---|
| ORD ID | ord-8addf26515aa4e59a47bf6a4ed5ed78c |
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| Source note | uspto-grants-2007_01 |
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