HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Acetyl-5-nitroindolin-2-one → 1-Acetyl-5-aminoindolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Acetyl-5-nitroindolin-2-one | HCID 2839329 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Acetyl-5-aminoindolin-2-one | HCID 12046998 | — |
Reaction Steps
30.0 g (136 mmol) of 1-acetyl-5-nitro-2-indolinone are dissolved in a mixture of 650 ml of dichloromethane and 650 ml of methanol and after the addition of 5 g of 10% palladium on activated charcoal the mixture is hydrogenated for 45 minutes with hydrogen. Then the catalyst is filtered off and evaporated down.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07160901B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-20d1f7e55882484bb6b38a2f3b1021d2 |
| Source note | uspto-grants-2007_01 |