Acetic Anhydride → HCID 69509829, compound

HRID 1373136Notes

Reaction equation

HRID 1373136 reaction equation
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([NH:13][S:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)(=[O:16])=[O:15])=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:23])(=[O:3])[CH3:2].[CH3:24][CH2:25][O:26][C:27](OCC)(OCC)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.[C:40](OC(=O)C)(=[O:42])[CH3:41]>>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N:13]([C:40](=[O:42])[CH3:41])[S:14]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)(=[O:16])=[O:15])=[CH:10][CH:11]=2)[C:6](=[C:27]([O:26][CH2:25][CH3:24])[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:5]1=[O:23])(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 74268Benzene, (triethoxymethyl)-HCID 120469991-Acetyl-5-phenylsulphonylamino-2-indolinone

Product 1

HCID 69509829HCID 69509829, compound

Procedure

8.0 g (24.2 mmol) of 1-acetyl-5-phenylsulphonylamino-2-indolinone are dissolved in 150 ml of acetic anhydride and after the addition of 20 ml (88.1 mmol) of triethyl orthobenzoate refluxed for 6 hours. The solvent is distilled off, the residue is triturated with ether, suction filtered and dried.

Workup

  1. temperaturerefluxed for 6 hours
  2. distillationThe solvent is distilled off
  3. customthe residue is triturated with ether, suction
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-4a0b5256389248a6a841cdecfe507471
Source dataset
uspto-grants-2007_01
Patent number
US07160901B2

Reaction notes

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