Methanol → HCID 21074214, compound

Participants

Reaction Steps

Methyl 3,5-diphenoxymethylbenzoate (525 mg 1.51 mM) 2.0M sodium hydroxide (2.3 n 4.6 mm) methanol (5 ml) water (3 ml) and THF (10 ml) were stirred together at room temperature for 3 hours. After concentrating to ½ volume the mixture was acidified with 2.0M hydrochloric acid and partitioned between ethyl acetate and water. The organic extracts were washed with water, dried (magnesium sulphate) filtered and evaporated to give 3,5-diphenoxymethylbenzoic acid as a colourless solid (500 mg, 99%); H1 NMR δ (d6-DMSO) 5.19 (4 H s) 6.9–7.18 (6 H m) 7.28 (4 H t) 7.78 (1 H s) 7.95 (2 H s); MS [MH]− 333.

Provenance & Evidence