Ethyl Acetate → HCID 86596373, compound

Participants

Reaction Steps

A solution of pentafluorophenol (21.6 g, 0.113 mol) DMF (100 ml) at room temperature was slowly added to a suspension of 5-fluoro-6-(2-fluoro-4-iodo-phenylamino)-3-methyl-3H-benzoimidazole-5-carboxylic acid (40.0 g , 0.093 mol) in 165 ml of THF, followed by dicyclohexylcarbodiimide (24.14 g, 0.118 mol). The mixture was stirred overnight at room temperature (TLC-EtOAc), evaporated under vacuum and is added 200 g of crushed ice to the residual DMF solution. The light yellow compound separated was filtered and vacuum dried to give the title compound (crude), which is directly proceeded to next step without purification. Yield: 55 g (99%).

Provenance & Evidence