Water → HCID 178463218, compound
Reaction equation
[C:1](#[N:3])[CH3:2].[F:4][C:5]1[CH:41]=[CH:40][C:8]([CH2:9][CH2:10][NH:11][C:12](=[N:14][C:15]2[CH:23]=[C:22]3[C:18]([CH2:19][C@@H:20]([OH:39])[C@@H:21]3[NH:24][C:25]([C:27]3[CH:32]=[CH:31][C:30]([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)=[CH:29][CH:28]=3)=[O:26])=[CH:17][CH:16]=2)[CH3:13])=[CH:7][CH:6]=1.[OH2:42]>CO>[OH2:26].[F:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:9][CH2:10][NH:11][C:12](=[N:14][C:15]2[CH:23]=[C:22]3[C:18]([CH2:19][C@@H:20]([OH:39])[C@@H:21]3[NH:24][C:25]([C:27]3[CH:32]=[CH:31][C:30]([C:33]4[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=4)=[CH:29][CH:28]=3)=[O:26])=[CH:17][CH:16]=2)[CH3:13])=[CH:40][CH:41]=1.[C:33]1([C:30]2[CH:29]=[CH:28][CH:27]=[CH:32][CH:31]=2)[CH:34]=[CH:35][C:2]([C:1]([NH:3][C@@H:21]2[C:22]3[C:18](=[CH:17][CH:16]=[C:15]([N:14]=[C:12]([NH:11][CH2:10][CH2:9][C:8]4[CH:7]=[CH:6][C:5]([F:4])=[CH:41][CH:40]=4)[CH3:13])[CH:23]=3)[CH2:19][C@H:20]2[OH:39])=[O:42])=[CH:37][CH:38]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Dissolve biphenyl-4-carboxylic acid (R)-(6-(1-((4-fluorobenzyl)methylamino)ethylideneamino)-2(R)-hydroxyindan-1-yl)amide acetonitrile solvate (2.0 g) in methanol (24 mL) at 20–23° C. Add water (5 mL) to the solution, followed by hemihydrate seed crystals (20 mg). Stir the mixture for 2 h at 20–23° C., then cool to 0–5° C. Filter the mixture, wash with a solution of methanol (8 mL) and water (2 mL), and dry at 50–60° C. under vacuum for 16 h to give 1.66 g of the title compound.
Workup
- temperaturecool to 0–5° C
- filtrationFilter the mixture
- washwash with a solution of methanol (8 mL) and water (2 mL)
- customdry at 50–60° C. under vacuum for 16 h
Sources & evidence
- ORD record
- ord-6b958ac2e9794bcd84139f6074d2c463
- Source dataset
- uspto-grants-2007_01
- Patent number
- US07160922B2
Reaction notes
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