Triethylamine → HCID 21073052, compound

Participants

Reaction Steps

A mixture of N-[2-[3-(tert-butoxycarbonylaminomethyl)phenoxy]-4-chlorophenyl]-N-(3,4-dichlorobenzyl)succinamic acid (0.91 g, 1.5 mmols), 2-fluorobenzylamine (0.23 g, 1.8 mmols), diethyl cyanophosphate (0.25 ml, 1.8 mmols), triethylamine (0.25 ml, 1.8 mmols) and N,N-dimethylformamide (10 ml) was stirred at room temperature for 2 hours. The reaction mixture was poured into water, and extracted with ethyl acetate. The extract was washed with water, and then dried with anhydrous magnesium sulfate. This was concentrated under reduced pressure, and the residue was purified through silica gel column chromatography to give an amorphous solid of N-[2-[3-(tert-butoxycarbonylaminomethyl)phenoxy]-4-chlorophenyl]-N-(3,4-dichlorobenzyl)-N′-(2-fluorobenzyl)succinamide (0.61 g, 57%).

Provenance & Evidence