HCID 17815508, compound → HCID 17815681, compound

Participants

Reaction Steps

5% carbon-palladium (1.3 g) was added to an ethyl acetate (100 ml) solution of 2-tert-butoxycarbonyl-5-(5-chloro-2-nitrophenoxy)-1,2,3,4-tetrahydroisoquinoline (4.25 g, 10.5 mmols). The resulting mixture was hydrogenated at room temperature under atmospheric pressure. The catalyst was removed through filtration, and the filtrate was concentrated under reduced pressure. The residue was purified through silica gel column chromatography to give an oil of 5-(2-amino-5-chlorophenoxy)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline (2.95 g, 75%).

Provenance & Evidence