Dimethylformamide → HCID 21072942, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of tert-butyl[3-(2-amino-5-chlorophenoxy)benzyl]carbamate (10.5 g. 30 mmols), ethyl 5-bromovalerate (10.2 ml, 60 mmols), potassium carbonate (4.2 g, 30 mmols) and N,N-dimethylformamide (100 ml) was stirred at 60° C. for 96 hours. The reaction mixture was cooled, poured into water, and extracted with ethyl acetate. The extract was washed with water, and then dried with anhydrous magnesium sulfate. This was concentrated under reduced pressure, and the residue was purified through silica gel column chromatography to give an oil of ethyl 5-[2-[3-(tert-butoxycarbonylaminomethyl)phenoxy]-4-chlorophenyl]aminovalerate (8.65 g, 60.4%).

Provenance & Evidence