HCID 21073050, compound → HCID 21072954, compound

Participants

Reaction Steps

A 2 N hydrochloric acid/ethyl acetate solution (4 ml) of N-[2-[3-(tert-butoxycarbonylaminomethyl)phenoxy]-4-chlorophenyl]-N-[2-(3-phenylbutyryl)aminoethyl]-4-phenylbenzamide (0.1 g, 0.14 mmols) was stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure. The solid precipitated was taken out through filtration, and washed with ethyl ether to give an amorphous solid of N-[2-[3-(aminomethyl)phenoxy]-4-chlorophenyl]-N-[2-(3-phenylbutyryl)aminoethyl]-4-phenylbenzamide hydrochloride (0.087 g, 95%).

Provenance & Evidence