Hydrogen chloride-ethyl acetate → HCID 69351864, compound

Participants

Reaction Steps

A 4 N hydrochloric acid/ethyl acetate (3 ml) solution was added to an ethyl acetate (3 ml) solution of tert-butyl(1S)-1-[3-[2-[(4-phenylbenzoyl)[3-[[[(2-fluorobenzyl)amino]carbonyl]amino]propyl]amino]-5-chlorophenoxy]phenyl]ethylcarbamate (0.36 g, 0.48 mmols), and stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure. The solid precipitated was taken out through filtration, and washed with ethyl ether to give an amorphous solid of N-[2-[3-[(1S)-1-aminoethyl]phenoxy]-4-chlorophenyl]-N-[3-[[[(2-fluorobenzyl)amino]carbonyl]amino]propyl]-4-phenylbenzamide hydrochloride (0.31 g, 95%).

Provenance & Evidence