HCID 21073088, compound → HCID 21073087, compound

Participants

Reaction Steps

5% carbon-palladium (1.0 g) was added to an ethyl acetate (100 ml) solution of tert-butyl[1-[3-(5-chloro-2-nitrophenoxy)phenyl]-1-methylethyl]carbamate (3.3 g, 8.1 mmols). The resulting mixture was hydrogenated at room temperature under atmospheric pressure for 3 hours. The catalyst was removed through filtration, and the filtrate was concentrated under reduced pressure. The residue was purified through silica gel column chromatography to give an amorphous solid of tert-butyl[1-[3-(2-amino-5-chlorophenoxy)phenyl]-1-methylethyl]carbamate (2.7 g, 89%).

Provenance & Evidence