HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1373300Generated: October 30, 2026
Phosphorus oxychloride → 7-Benzyloxy-4-chloro-5-tetrahydropyran-4-yloxyquinazoline
https://huagongshe.com/reaction/1373300
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 7-Benzyloxy-5-tetrahydropyran-4-yloxy-3,4-dihydroquinazolin-4-one | HCID 135830911 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 7-Benzyloxy-4-chloro-5-tetrahydropyran-4-yloxyquinazoline | HCID 22140822 | — |
Reaction Steps
A mixture of 7-benzyloxy-5-tetrahydropyran-4-yloxy-3,4-dihydroquinazolin-4-one (9 g), phosphoryl chloride (2.8 ml), di-isopropylethylamine (11.4 ml) and 1,2-dichloroethane (130 ml) was stirred and heated to 80° C. for 3 hours. The mixture was evaporated to give 7-benzyloxy-4-chloro-5-tetrahydropyran-4-yloxyquinazoline which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07160891B2 |
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| Source dataset | uspto-grants-2007_01 |
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| ORD ID | ord-37c58e4f4bbf458fa403026ee092f4c8 |
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| Source note | uspto-grants-2007_01 |
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