HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Boc-4-(3-hydroxypropyl)piperazine → HCID 22140803, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Boc-4-(3-hydroxypropyl)piperazine | HCID 16217800 | — |
| Reactant | HCID 135830927 | HCID 135830927 | — |
| Product | HCID 22140803 | HCID 22140803 | 72.5% |
Reaction Steps
Using an analogous procedure to that described in Example 12, 4-(2,4-dichloro-5-methoxyanilino)-7-hydroxy-5-tetrahydropyran-4-yloxyquinazoline (0.109 g) was reacted with 1-tert-butoxycarbonyl-4-(3-hydroxypropyl)piperazine (0.074 g) to give 4-(2,4-dichloro-5-methoxyanilino)-7-[3-(4-tert-butoxycarbonylpiperazin-1-yl)propoxy]-5-tetrahydropyran-4-yloxyquinazoline (0.12 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07160891B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-d855d9e8cc494e418b4b17f4b515350b |
| Source note | uspto-grants-2007_01 |