Agomelatine → N-(2-(7-hydroxy-1-naphthyl)ethyl)acetamide

HRID 1373474Notes

Reaction equation

HRID 1373474 reaction equation
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[CH2:13][CH2:14][NH:15][C:16](=[O:18])[CH3:17])=[CH:5][CH:4]=1>ClCCl>[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[CH2:13][CH2:14][NH:15][C:16](=[O:18])[CH3:17])=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 82148Agomelatine

Product 1

HCID 11775984N-(2-(7-hydroxy-1-naphthyl)ethyl)acetamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Under an inert atmosphere, 27.5 mmol of boron tribromide/dimethyl sulphide complex are dissolved in 100 ml of dichloromethane and stirred for 15 minutes at ambient temperature. A solution of 13.7 mmol of N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide in 50 ml of dichloromethane is added, and the reaction mixture is heated at reflux for 30 hours. After cooling, the reaction mixture is cautiously hydrolysed and the dichloromethane is evaporated off. The mixture is then extracted with ethyl acetate and the combined organic phases are washed with an aqueous 1M potassium hydrogen carbonate solution. The organic phase is dried over magnesium sulphate and concentrated to yield the title compound. White solid.

Workup

  1. temperaturethe reaction mixture is heated
  2. temperatureat reflux for 30 hours
  3. temperatureAfter cooling
  4. customthe dichloromethane is evaporated off
  5. extractionThe mixture is then extracted with ethyl acetate
  6. washthe combined organic phases are washed with an aqueous 1M potassium hydrogen carbonate solution
  7. dry with materialThe organic phase is dried over magnesium sulphate
  8. concentrationconcentrated

Sources & evidence

ORD record
ord-9b50b30f6d2940dba5ce6e19f3ed85b8
Source dataset
uspto-grants-2007_01
Patent number
US07161035B2

Reaction notes

Loading…