1-(2-Chloro-6-piperazin-1-yl-phenyl)-ethanone → 7-{4-[4-(2-Acetyl-3-chloro-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-[1,8]naphthyridin-2-one

Participants

Reaction Steps

In a manner similar to that of other examples, above, 1-(2-chloro-6-piperazin-1-yl-phenyl)-ethanone was coupled by reductive amination to 4-(7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde followed by typical workup and purification to give the title compound, mp 115° C. MS: APCI: M+1: 457.2 (Exact Mass: 456.19).

Provenance & Evidence