HCID 21073145, compound → HCID 21073602, compound

HRID 1373537Notes

Reaction equation

HRID 1373537 reaction equation
Cl.[CH2:2]([C:4]1[C:9]([F:10])=[CH:8][CH:7]=[CH:6][C:5]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1)[CH3:3].[O:17]=[C:18]1[NH:27][C:26]2[N:25]=[C:24]([O:28][CH2:29][CH2:30][CH2:31][CH:32]=O)[CH:23]=[CH:22][C:21]=2[CH2:20][CH2:19]1>>[CH2:2]([C:4]1[C:9]([F:10])=[CH:8][CH:7]=[CH:6][C:5]=1[N:11]1[CH2:12][CH2:13][N:14]([CH2:32][CH2:31][CH2:30][CH2:29][O:28][C:24]2[N:25]=[C:26]3[C:21]([CH2:20][CH2:19][C:18](=[O:17])[NH:27]3)=[CH:22][CH:23]=2)[CH2:15][CH2:16]1)[CH3:3]

Participants

3

Reactant 2

HCID 21073145HCID 21073145, compoundHCID 210733774-((7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)oxy)butanal

Product 1

HCID 21073602HCID 21073602, compound

Procedure

In a manner similar to that of other examples above, 1-(2-ethyl-3-fluoro-phenyl)-piperazine hydrochloride was coupled by reductive amination to 4-(7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde followed by typical workup and purification to give the title compound. MS: APCI: M+1: 427.2 (Exact Mass: 426.24).

Workup

  1. customfollowed by typical workup and purification

Sources & evidence

ORD record
ord-f78fedd876454a98b7ce1322c97b65a3
Source dataset
uspto-grants-2007_01
Patent number
US07160888B2

Reaction notes

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