4-((7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)oxy)butanal → HCID 21073696, compound

HRID 1373542Notes

Reaction equation

HRID 1373542 reaction equation
Cl.[CH3:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[N:4]=1.[O:15]=[C:16]1[NH:25][C:24]2[N:23]=[C:22]([O:26][CH2:27][CH2:28][CH2:29][CH:30]=O)[CH:21]=[CH:20][C:19]=2[CH2:18][CH2:17]1>>[CH3:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([N:9]2[CH2:10][CH2:11][N:12]([CH2:30][CH2:29][CH2:28][CH2:27][O:26][C:22]3[N:23]=[C:24]4[C:19]([CH2:18][CH2:17][C:16](=[O:15])[NH:25]4)=[CH:20][CH:21]=3)[CH2:13][CH2:14]2)[N:4]=1

Participants

3

Reactant 2

HCID 210733774-((7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)oxy)butanalHCID 21073407HCID 21073407, compound

Product 1

HCID 21073696HCID 21073696, compound

Procedure

In a manner similar to that of other examples above, 4-methyl-2-piperazin-1-yl-pyrimidine hydrochloride (U.S. Pat. No. 6,303,603) was coupled by reductive amination to 4-(7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde followed by typical workup and purification to give the title compound. MS: APCI: M+1: 397.2 (Exact Mass: 396.23).

Workup

  1. customfollowed by typical workup and purification

Sources & evidence

ORD record
ord-de074e11efd64272b4d3cea1138bb5d8
Source dataset
uspto-grants-2007_01
Patent number
US07160888B2

Reaction notes

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