1-(3-Chloro-2-ethyl-phenyl)-piperazine hydrochloride → 7-{4-[4-(3-Chloro-2-ethyl-phenyl)-piperazin-1-yl]-butoxy}-1H-[1,8]naphthyridin-2-one

Participants

Reaction Steps

In a manner similar to that of other examples above, 1-(3-chloro-2-ethyl-phenyl)-piperazine hydrochloride was coupled by reductive amination to 4-(7-oxo-7,8-dihydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde followed by typical workup and purification to give the title compound. MS: APCI: M+1: 441.2 (Exact Mass: 440.20).

Provenance & Evidence