Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(2-Chloro-3-piperazin-1-yl-phenyl)-ethanone trifluoroacetate → 7-{4-[4-(3-Acetyl-2-chloro-phenyl)-piperazin-1-yl]-butoxy}-1H-[1,8]naphthyridin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(2-Chloro-3-piperazin-1-yl-phenyl)-ethanone trifluoroacetate | HCID 21073138 | — |
| 반응물 | 4-(7-Oxo-7,8-dihydro-1,8-naphthyridin-2-yloxy)butanal | HCID 21073380 | — |
| 생성물 | 7-{4-[4-(3-Acetyl-2-chloro-phenyl)-piperazin-1-yl]-butoxy}-1H-[1,8]naphthyridin-2-one | HCID 21073648 | — |
반응 단계
In a manner similar to that of other examples above, 1-(2-chloro-3-piperazin-1-yl-phenyl)-ethanone trifluoroacetate was coupled by reductive amination to 4-(7-oxo-7,8-dihydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde followed by typical workup and purification to give the title compound, mp 108–110° C. MS: APCI: M+1: 455.2 (Exact Mass: 454.18).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07160888B2 |
| 출처 데이터셋 | uspto-grants-2007_01 |
| ORD ID | ord-f27b2e2cea7f42c49310decc16ac5fe2 |
| 출처 메모 | uspto-grants-2007_01 |