HCID 21073281, compound → HCID 21073820, compound

HRID 1373561Notes

Reaction equation

HRID 1373561 reaction equation
Br.[N:2]1([C:8]2[N:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[O:14]=[C:15]1[NH:24][C:23]2[N:22]=[C:21]([O:25][CH2:26][CH2:27][CH2:28][CH:29]=O)[CH:20]=[CH:19][C:18]=2[CH:17]=[CH:16]1>>[N:13]1[CH:12]=[CH:11][CH:10]=[N:9][C:8]=1[N:2]1[CH2:7][CH2:6][N:5]([CH2:29][CH2:28][CH2:27][CH2:26][O:25][C:21]2[N:22]=[C:23]3[C:18]([CH:17]=[CH:16][C:15](=[O:14])[NH:24]3)=[CH:19][CH:20]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 21073281HCID 21073281, compoundHCID 210733804-(7-Oxo-7,8-dihydro-1,8-naphthyridin-2-yloxy)butanal

Product 1

HCID 21073820HCID 21073820, compound

Procedure

In a manner similar to that of other examples above, 2-piperazin-1-yl-pyrimidine hydrobromide was coupled by reductive amination to 4-(7-Oxo-7,8-dihydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde followed by typical workup and purification to give the title compound, MS: APCI: M+1: 381.1 (Exact Mass: 380.20).

Workup

  1. customfollowed by typical workup and purification

Sources & evidence

ORD record
ord-756bc1b8ab0c46bbbfe593590f49d6dd
Source dataset
uspto-grants-2007_01
Patent number
US07160888B2

Reaction notes

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