4-(7-Oxo-7,8-dihydro-1,8-naphthyridin-2-yloxy)butanal → HCID 21073693, compound

HRID 1373562Notes

Reaction equation

HRID 1373562 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[N:5]=1.[O:16]=[C:17]1[NH:26][C:25]2[N:24]=[C:23]([O:27][CH2:28][CH2:29][CH2:30][CH:31]=O)[CH:22]=[CH:21][C:20]=2[CH:19]=[CH:18]1>>[CH3:2][O:3][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([N:10]2[CH2:11][CH2:12][N:13]([CH2:31][CH2:30][CH2:29][CH2:28][O:27][C:23]3[N:24]=[C:25]4[C:20]([CH:19]=[CH:18][C:17](=[O:16])[NH:26]4)=[CH:21][CH:22]=3)[CH2:14][CH2:15]2)[N:5]=1

Participants

3

Reactant 2

HCID 210733804-(7-Oxo-7,8-dihydro-1,8-naphthyridin-2-yloxy)butanalHCID 21073400HCID 21073400, compound

Product 1

HCID 21073693HCID 21073693, compound

Procedure

In a manner similar to that of other examples above, 4-methoxy-2-piperazin-1-yl-pyrimidine hydrochloride (U.S. Pat. No. 6,303,603) was coupled by reductive amination to 4-(7-oxo-7,8-dihydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde followed by typical workup and purification to give the title compound. MS: APCI: M+1: 411.2 (Exact Mass: 410.21).

Workup

  1. customfollowed by typical workup and purification

Sources & evidence

ORD record
ord-59fe7a6ca1224d29822d605ea749ff58
Source dataset
uspto-grants-2007_01
Patent number
US07160888B2

Reaction notes

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