1-Bromonaphthalene → HCID 21073477, compound

HRID 1373570Notes

Reaction equation

HRID 1373570 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[N:20]=[C:19]3[C:14]([CH2:15][CH2:16][C:17](=[O:21])[NH:18]3)=[CH:13][CH:12]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Br[C:23]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH:26]=[CH:25][CH:24]=1>>[C:31]1([N:4]2[CH2:5][CH2:6][N:1]([CH2:7][CH2:8][CH2:9][O:10][C:11]3[N:20]=[C:19]4[C:14]([CH2:15][CH2:16][C:17](=[O:21])[NH:18]4)=[CH:13][CH:12]=3)[CH2:2][CH2:3]2)[C:32]2[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:28]=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 70011-BromonaphthaleneHCID 21073479HCID 21073479, compound

Product 1

HCID 21073477HCID 21073477, compound

Procedure

In a similar manner to the example shown above, 7-(3-piperazin-1-yl-propoxy)-3,4-dihydro-1H-[1,8]naphthyridin-2-one was coupled to 1-bromo-naphthalene to give the title compound (0.189 g). MS: APCI: M+1: 417.2 (Exact Mass: 416.22).

Sources & evidence

ORD record
ord-b2f4656b28ca46b4bdaeb09e8796787e
Source dataset
uspto-grants-2007_01
Patent number
US07160888B2

Reaction notes

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